Population
Undifferentiated PC-12 (pheochromocytoma) cells
Comparison
Epinephrine or carbachol vs Control (untreated cells)
Design
Preclinical
Authors
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Animal data support PTX-sensitive G-protein mediation of alpha2-adrenergic and muscarinic Ca2+ channel inhibition; leaves open human translation.
Activated alpha 2-adrenergic and muscarinic receptors inhibit dihydropyridine-sensitive Ca2+ channels via pertussis toxin-sensitive G proteins without the involvement of cAMP.
Gollasch et al. (1991) studied this question.
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