Key result
In pheochromocytoma PC12 cells, ATP-evoked catecholamine release is mediated by Ca2+ influx through ATP-activated channels rather than voltage-gated Ca2+ channels.
Population
Pheochromocytoma PC12 cells
Comparison
Extracellular ATP (≥ 100 µM) vs Extracellular KCl or varying extracellular…
Design
Preclinical
Authors
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PC12 findings should not guide pheochromocytoma care; leaves open ATP-channel role in human catecholamine disorders.
In PC12 cells, ATP-evoked catecholamine release is mediated by Ca2+ influx through ATP-activated channels rather than voltage-gated Ca2+ channels.
Nakazawa et al. (1992) studied Pheochromocytoma PC12 cells. ATP was evaluated on Catecholamine release and intracellular free Ca2+ concentration. In pheochromocytoma PC12 cells, ATP-evoked catecholamine release is mediated by Ca2+ influx through ATP-activated channels rather than voltage-gated Ca2+ channels.
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