September 1, 1990The Journal of PhysiologyOpen Access

An ATP‐activated conductance in pheochromocytoma cells and its suppression by extracellular calcium.

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Population

PC12 pheochromocytoma cells

Design

Preclinical

Authors

KNKen NakazawaSaitama Medical University KFKannosuke FujimoriShowa University ATAkira TakanakaShowa University

Discussion

Member takes

Implication

Suggests caution extrapolating ATP-gated Ca2+ fluxes from PC12 to cardiomyocytes; extends cell-type models but remains hypothesis-generating.

Structured PICO

Population

PC12 pheochromocytoma cells

Intervention

Extracellular application of ATP (100 microM) and varying concentrations of extracellular Ca2+ and other ions

Outcome

ATP-activated inward current characteristics (amplitude, reversal potential, desensitization, ion selectivity)surrogate

In PC12 pheochromocytoma cells, extracellular calcium permeates and blocks the ATP-activated conductance pathway, a regulation different from that in smooth muscle cells.

Cite This Study

Nakazawa et al. (1990) studied this question.

synapsesocial.com/papers/6a96cbe3672df19136a6d641 https://doi.org/10.1113/jphysiol.1990.sp018211

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Implication

Suggests caution extrapolating ATP-gated Ca2+ fluxes from PC12 to cardiomyocytes; extends cell-type models but remains hypothesis-generating.

An ATP‐activated conductance in pheochromocytoma cells and its suppression by extracellular calcium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

An ATP‐activated conductance in pheochromocytoma cells and its suppression by extracellular calcium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider