What does this research mean for the field?

Flow-mediated reduction in pulse wave velocity reflects endothelial function and is impaired in patients with chronic heart failure, offering a sensitive measure of endothelial dysfunction. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 2, 2005European Heart Journal

Flow-mediated changes in pulse wave velocity: a new clinical measure of endothelial function

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Why the study?

A novel method to assess endothelial function by measuring hyperaemic changes in pulse wave velocity was tested for potential clinical use.

Can flow-mediated changes in pulse wave velocity be used as a clinical measure of endothelial function?

Comparison

Flow-mediated changes in upper and lower limb PWV in healthy subjects versus patients with stable chronic heart failure

Design

Cross-sectional study

Authors

KNKaterina Κ. NakaHeart Failure & Transplant ATAnn C. TweddelCastle Hill Hospital SDSagar N. DoshiQueen Elizabeth Hospital Birmingham

Discussion

Member takes

Implication

Flow-mediated PWV changes may mark endothelial dysfunction in CHF; leaves open clinical adoption pending prospective validation.

Structured PICO

Can flow-mediated changes in pulse wave velocity be used as a clinical measure of endothelial function?

Population

32 subjects total: 17 healthy subjects and 7 patients with stable chronic heart failure (CHF) for primary comparison, plus 8 healthy subjects for corroborative measurements.

Intervention

Measurement of flow-mediated changes in upper and lower limb pulse wave velocity (PWV) induced by distal hyperaemia.

Comparator

Healthy subjects compared to patients with stable chronic heart failure (CHF).

Outcome

Flow-mediated changes in upper and lower limb pulse wave velocity (PWV).surrogate

Measuring flow-mediated changes in pulse wave velocity offers a potentially sensitive and practical method for assessing endothelial dysfunction.

Cite This Study

Naka et al. (2005) studied this question.

synapsesocial.com/papers/6a8336b4d7df55868faf903f https://doi.org/10.1093/eurheartj/ehi619

Topics

Heart failure HFrEF treatment

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Flow-mediated changes in pulse wave velocity: a new clinical measure of endothelial function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Flow-mediated changes in pulse wave velocity: a new clinical measure of endothelial function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider