Why the study?
Does nadolol once daily improve symptoms and exercise capacity compared to propranolol four times daily in patients with angina pectoris?
Does nadolol once daily improve symptoms and exercise capacity compared to propranolol four times daily in patients with angina pectoris?
Once-daily nadolol is as effective as four-times-daily propranolol for symptom control in angina, with potentially better exercise performance.
Supports once-daily nadolol for angina symptom control with superior exercise tolerance; extends comparative beta-blocker data in stable angina.
Twenty-nine anginal patients were randomly allocated to nadolol once daily, or propranolol four times daily and titrated to optimum dosage over 14 weeks under double-blind conditions: all patients then continued on nadolol once daily. Efficacy was assessed by numbers of anginal attacks and nitroglycerin (GTN) usage, and exercise EKG on the bicycle ergometer. Results showed the two drugs to have similar effects regarding anginal attacks and GTN consumption, but nadolol produced better performance in exercise time. In the extended treatment period on nadolol, the improvements over baseline readings were maintained. No serious side-effects or laboratory abnormalities were encountered.
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Gerold Prager (1979) studied this question.
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