What question did this study set out to answer?

To determine the effects of sustained metoprolol treatment on 24-hour continuous ambulatory arterial blood pressure and daily circadian rhythms in hypertensive patients.

December 1, 1979Clinical Science

The Effects of Metoprolol on Ambulatory Blood Pressure

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Why the study?

Does metoprolol reduce ambulatory blood pressure and heart rate in hypertensive patients?

Population

12 hypertensive patients

Comparison

Metoprolol 100 mg twice daily for 2-4 months vs Baseline (before treatment)

Design

Cohort

Follow-up

2-4 months

Authors

SMStewart MannUniversity of Otago MCM. W. Millar CraigUniversity of Calgary DADouglas G. AltmanUniversity of Oxford

Discussion

Member takes

Implication

May support metoprolol use in hypertension via ambulatory monitoring; leaves open RCT confirmation of outcomes.

Key Points

To determine the effects of sustained metoprolol treatment on 24-hour continuous ambulatory arterial blood pressure and daily circadian rhythms in hypertensive patients.
Continuous 24-hour arterial pressure monitoring was performed via an indwelling cannula in N=12 hypertensive patients prior to starting therapy.
Patients received metoprolol at 100 mg twice daily, with identical 24-hour continuous hemodynamic monitoring repeated after 2 to 4 months of treatment.
Metoprolol therapy significantly reduced heart rate, systolic blood pressure, and diastolic blood pressure over the 24-hour monitoring period.
Circadian patterns of blood pressure and heart rate fluctuations remained qualitatively similar before and during treatment.

Structured PICO

Does metoprolol reduce ambulatory blood pressure and heart rate in hypertensive patients?

Population

12 hypertensive patients

Intervention

Metoprolol 100 mg twice daily for 2-4 months

Comparator

Baseline (before treatment)

Outcome

Heart rate and systolic and diastolic pressures measured via continuous monitoring over 24 hsurrogate

Metoprolol significantly reduces ambulatory blood pressure and heart rate without altering their circadian patterns in hypertensive patients.

Cite This Study

Mann et al. (1979) studied this question.

synapsesocial.com/papers/6a833752a250d11ff44cdf91 https://doi.org/10.1042/cs057375s

Topics

Hypertension management

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The Effects of Metoprolol on Ambulatory Blood Pressure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

The Effects of Metoprolol on Ambulatory Blood Pressure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider