Key result
Metoprolol reduces 24-hour MAP below 113 mmHg in ~80% of patients, improving ventricular arrhythmias.
Why the study?
Does metoprolol 100 mg once daily reduce 24-hour blood pressure and arrhythmias in hypertensive out-patients?
Population
20 hypertensive out-patients aged 31-69 years with a mean 24-hour blood pressure of >160/90 mm Hg.
Comparison
Metoprolol 100 mg once daily. vs Baseline (pre-treatment).
Design
Cohort
Authors
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Metoprolol 100 mg daily may aid 24-hour BP control and arrhythmias in outpatients; hypothesis-generating without randomized confirmation.
Does metoprolol 100 mg once daily reduce 24-hour blood pressure and arrhythmias in hypertensive out-patients?
Absolute Event Rate: 80% vs 0%
Metoprolol 100 mg once daily effectively reduces 24-hour ambulatory blood pressure and improves ventricular arrhythmias in hypertensive patients.
Palma et al. (1985) studied Hypertension (n=20). Metoprolol vs. Baseline (pre-treatment) was evaluated on Reduction of mean 24-hour mean arterial pressure (MAP) to below 113 mm Hg. Metoprolol (100 mg once daily) reduced mean 24-hour mean arterial pressure to below 113 mm Hg in 80% of hypertensive patients and improved ECG signs of ventricular arrhythmias.
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