Key result
Metoprolol lowers blood pressure and heart rate in hypertensive patients with asthma without altering FEV1.
Why the study?
Does metoprolol safely reduce blood pressure and heart rate in hypertensive patients, including those with asthma?
Does metoprolol safely reduce blood pressure and heart rate in hypertensive patients, including those with asthma?
Metoprolol effectively lowers blood pressure and heart rate in hypertensive patients without significantly impairing lung function in those with concomitant asthma.
Supports metoprolol consideration in hypertensive asthmatics; leaves open randomized confirmation before practice change.
Ninety-nine patients took part in a multicentre, long-term study of metoprolol in the treatment of hypertension. Significant reductions in blood pressure and heart rate were achieved by the use of metoprolol alone, or in combination with other antihypertensive agents. Side effects were similar to those seen with other beta-adrenergic blocking agents, except that bronchospasm and cold extremities were rarely encountered. Results of monitoring for the abnormal eye symptoms and antinuclear factor titre are discussed. In a second study, 14 hypertensive patients with asthma (11 patients) or history thereof (three patients), received metoprolol for their hypertension. In general, no significant change in forced expiratory volume in one second (FEV1) was found, despite significant reduction in blood pressure and heart rate. The concomitant use of a beta2-agonist is discussed.
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Hua et al. (1978) studied Hypertension (n=113). Metoprolol was evaluated on Blood pressure and heart rate. Metoprolol significantly reduced blood pressure and heart rate in hypertensive patients, including those with asthma, without causing significant changes in FEV1.
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