Why the study?
Does hydrochlorothiazide 12.5 mg reduce blood pressure similarly to bendroflumethiazide 2.5 mg in previously untreated hypertensives?
Does hydrochlorothiazide 12.5 mg reduce blood pressure similarly to bendroflumethiazide 2.5 mg in previously untreated hypertensives?
Low doses of hydrochlorothiazide and bendroflumethiazide provide comparable and significant blood pressure reduction with minimal metabolic side effects in previously untreated hypertensives.
Clinicians may select either low-dose thiazide confidently; confirms metabolic equivalence in untreated hypertensives.
The effect and tolerability of hydrochlorothiazide 12.5 mg and bendroflumethiazide 2.5 mg were compared in 36 previously untreated hypertensives in a double-blind randomized multicenter trial. The results show a significant blood pressure reduction with both hydrochlorothiazide 12.5 mg and bendroflumethiazide 2.5 mg both at month 6 and 12 compared with month 0. Serum potassium was not significantly changed after twelve months of therapy with either of the thiazide compared with month 0. There was no significant difference between hydrochlorothiazide and bendroflumethiazide with respect to the hypotensive effect, the effect on potassium and uric acid in serum, fasting blood glucose, or any other variable studied. Few subjective side effects were reported.
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A 1984 study studied this question.
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