Why the study?
Do clarithromycin, roxithromycin, and azithromycin induce Q-T interval prolongation in rats compared to erythromycin?
Do clarithromycin, roxithromycin, and azithromycin induce Q-T interval prolongation in rats compared to erythromycin?
Roxithromycin and azithromycin have lower arrhythmogenic potency for Q-T interval prolongation compared to erythromycin and clarithromycin in a rat model.
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May indicate lower QT-prolonging potency for roxithromycin and azithromycin in rats; leaves open human arrhythmogenic relevance.
Ohtani et al. (2000) studied this question.
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