Why the study?
Does measurement of PLA2, CRP, and WBC improve the diagnosis of acute appendicitis in patients undergoing appendectomy?
Population
186 patients undergoing appendectomy after clinical diagnoses of acute appendicitis
Comparison
Measurement of group II phospholipase A2 in serum vs Measurement of white blood cell count and…
Design
Cohort
Authors
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May aid appendicitis exclusion when markers normal; hypothesis-generating and requires prospective validation before practice change.
Does measurement of PLA2, CRP, and WBC improve the diagnosis of acute appendicitis in patients undergoing appendectomy?
Normal values for WBC, CRP, and PLA2 can exclude acute appendicitis with a 100% predictive value, while CRP and PLA2 are better indicators of perforation or abscess than WBC.
Grönroos et al. (1994) studied this question.
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