Why the study?
Left ventricular lead implantation during CRT-D remains a tricky challenge in some patients with ischemic heart failure.
Does synchronized dual septal fascicular-area pacing improve electrical synchrony (QRS duration) in a patient with ischemic cardiomyopathy and cRBBB when standard left ventricular lead implantation fails?
Does synchronized dual septal fascicular-area pacing improve electrical synchrony (QRS duration) in a patient with ischemic cardiomyopathy and cRBBB when standard left ventricular lead implantation fails?
Synchronized pacing of the left anterior and posterior fascicular regions is a technically feasible bailout approach that successfully shortened QRS duration in a patient with ischemic cardiomyopathy when conventional CRT-D lead placement was unachievable.
Technical challenges in this CRT-D case should not alter practice; leaves open optimal LV lead strategies for cRBBB ischemic HF.
Cardiac resynchronization therapy - defibrillator (CRT-D) is an effective treatment for ischemic heart failure (HF). But, it is a tricky challenge for left ventricular lead implantation difficulties during CRT-D. We report an ischemic cardiomyopathy patient with complete right bundle branch block (cRBBB) underwent CRT-D. During the implantation, the left anterior fascicular (LAF) region pacing was not ideal, and the implantation of left ventricular lead in lateral posterior or posterior wall was difficult. Then, leads were changed to be implanted into anterior septal region (near the LAF) and posterior septal region (near the LPF) from right ventricle, respectively. Synchronized pacing of LAB and LPB was performed to replace the pacing of left bundle branch region and left ventricular lateral posterior wall. Then, the QRS duration was shortened from 160ms to 100ms. During one month in follow-up, the patient's quality of life was good and the pacing parameters were stable. This case illustrates a technically feasible, hypothesis-generating bailout approach for selected patients when conventional coronary sinus left ventricular lead placement and standard conduction system pacing are unsuccessful.
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Guan et al. (2026) studied this question.
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