Key result
Totally leadless left bundle branch area pacing via the WiSE-CRT system was feasible in three heart failure patients, achieving electrical resynchronization and clinical improvement in two survivors at 6 months.
Why the study?
Conventional CRT is not always feasible due to anatomical constraints, and 30 to 40% of patients are considered non-responders.
Does totally leadless left bundle branch area pacing via the WiSE-CRT system improve electrical and echocardiographic parameters in patients with heart failure?
Case Report (n=3)
No
Does totally leadless left bundle branch area pacing via the WiSE-CRT system improve electrical and echocardiographic parameters in patients with heart failure?
Totally leadless left bundle branch area pacing using the WiSE-CRT system is technically feasible and may offer an effective alternative to conventional CRT in high-risk heart failure patients.
Requires validation before clinical use; leaves open efficacy and safety of leadless LBBAP in larger HF trials.
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Deschamps et al. (2025) conducted a case report in Heart failure (n=3). WiSE-CRT system for left bundle branch area pacing was evaluated on Feasibility of left bundle branch area pacing via the left ventricular septal approach. Totally leadless left bundle branch area pacing via the WiSE-CRT system was feasible in three heart failure patients, achieving electrical resynchronization and clinical improvement in two survivors at 6 months.
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