What question did this study set out to answer?

June 1, 2004Neurosurgery

Correlation of Serum Brain Natriuretic Peptide With Hyponatremia and Delayed Ischemic Neurological Deficits After Subarachnoid Hemorrhage

View Full Paper

Ask AI

Bookmark

Why the study?

Does serum BNP level correlate with hyponatremia and delayed ischemic neurological deficits in patients with subarachnoid hemorrhage?

Population

40 consecutive patients admitted with subarachnoid hemorrhage (SAH)

Design

Cohort

Follow-up

14 days

Authors

MMMatthew J. McGirtUniversity of North Carolina at Charlotte RBRobert BlessingDuke University SNShahid M. NimjeeThe Ohio State University Wexner Medical Center

Discussion

Member takes

Implication

BNP may aid vasospasm risk stratification after SAH; leaves open whether it improves outcomes or warrants targeted interventions.

Key Points

To determine the temporal relationship between serum brain natriuretic peptide elevation, hyponatremia, and delayed ischemic neurological deficits, and evaluate its association with 2-week outcomes following subarachnoid hemorrhage.
Prospectively evaluated 40 consecutive patients admitted with subarachnoid hemorrhage who were managed to maintain euvolemia.
Measured serum brain natriuretic peptide and sodium every 12 hours for 14 days.
Assessed patients with transcranial Doppler every 48 hours and performed cerebral angiography upon the emergence of delayed neurological deficits.
Symptomatic cerebral vasospasm occurred in 16 of 40 patients (40%), with serum brain natriuretic peptide increasing 5.4-fold within 24 hours of onset and remaining independently associated with vasospasm (OR 1.28; 95% CI, 1.1–1.6).
A greater than threefold rise in admission brain natriuretic peptide was associated with hyponatremia (P < 0.05), with significantly higher levels in vasospasm patients at days 4–6 (285 ± 67 vs. 116 ± 30 pg/ml; P < 0.01).
Patients with increasing brain natriuretic peptide showed no change in 2-week Glasgow Coma Scale scores (0 ± 3), whereas patients without increases demonstrated significant recovery (3.0 ± 2; P < 0.05).

Structured PICO

Does serum BNP level correlate with hyponatremia and delayed ischemic neurological deficits in patients with subarachnoid hemorrhage?

Population

40 consecutive patients admitted with subarachnoid hemorrhage (SAH)

Outcome

Temporal relationship between serum BNP elevation, hyponatremia, and the onset of delayed ischemic neurological deficits, and correlation with 2-week Glasgow Coma Scale scoresurrogate

Increasing serum BNP levels after subarachnoid hemorrhage are independently associated with hyponatremia and delayed ischemic neurological deficits, and predict 2-week neurological outcomes.

Cite This Study

McGirt et al. (2004) studied this question.

synapsesocial.com/papers/6a83473734cda9cf27a6e484 https://doi.org/10.1227/01.neu.0000125016.37332.50

View Full Paper

Ask AI

Bookmark

Correlation of Serum Brain Natriuretic Peptide With Hyponatremia and Delayed Ischemic Neurological Deficits After Subarachnoid Hemorrhage

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Correlation of Serum Brain Natriuretic Peptide With Hyponatremia and Delayed Ischemic Neurological Deficits After Subarachnoid Hemorrhage

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider