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Does indomethacin-induced suppression of prostacyclin synthesis alter frusemide-stimulated renin secretion in the rat isolated perfused kidney?
Does indomethacin-induced suppression of prostacyclin synthesis alter frusemide-stimulated renin secretion in the rat isolated perfused kidney?
Frusemide-stimulated renin secretion in the rat kidney does not require intact renal PGI2 synthesis and is independent of beta-adrenergic mechanisms.
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Indomethacin does not alter frusemide-stimulated renin secretion in rat kidney; leaves open any role for PGI2 in human renin regulation.
Barden et al. (1984) studied this question.
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