Key result
Oral propranolol 160 mg daily for 7 days did not alter the increase in plasma renin activity following intravenous frusemide in normal and hypertensive subjects.
Why the study?
Does oral propranolol alter the plasma renin activity response to intravenous frusemide in normal and hypertensive subjects?
Does oral propranolol alter the plasma renin activity response to intravenous frusemide in normal and hypertensive subjects?
Concurrent propranolol administration does not prevent the enhanced renin activity associated with diuretic use, suggesting a potential limitation in the hypotensive action of combined beta-blocker and diuretic therapy.
May not blunt diuretic-induced renin release; leaves open whether this limits combined beta-blocker-diuretic efficacy in hypertension.
The response of plasma renin activity to frusemide 40 mg given intravenously, was examined before and after oral propranolol 160 mg daily for 7 days in normal and hypertensive subjects. 2. Although basal renin levels were often reduced, the increase following frusemide was essentially unaltered by propranolol therapy. 3. These findings indicate that enhanced renin activity associated with diuretic use may not be prevented by concurrent propranolol administration. Limitation of hypotensive action of combined beta-blocker diuretic therapy can therefore be anticipated. 4. Preservation of the renin stimulatory effect of frusemide during beta blockade confirms the value of this procedure in the investigation of mineralocorticoid and renovascular hypertension were discontinuation of treatment may be undesirable.
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Vandongen et al. (1980) studied Normal and hypertensive subjects. Oral propranolol vs. Before propranolol therapy (baseline) was evaluated on Response of plasma renin activity to intravenous frusemide 40 mg. Oral propranolol 160 mg daily for 7 days did not alter the increase in plasma renin activity following intravenous frusemide in normal and hypertensive subjects.
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