Why the study?
Does indomethacin inhibit the renin-aldosterone response to acute furosemide challenge in human volunteers?
Does indomethacin inhibit the renin-aldosterone response to acute furosemide challenge in human volunteers?
Indomethacin blunts the renin-aldosterone response to furosemide, providing evidence for the role of renal prostaglandins in modulating the renin-angiotensin-aldosterone axis.
NSAIDs may blunt acute RAAS activation by loop diuretics; supports prostaglandin-RAAS link but remains hypothesis-generating.
In 12 human volunteers, indomethacin was shown to inhibit renal prostaglandin produciton as reflected by RIA of urinary PGE2. The increases in plasma renin activity and plasma and urinary aldosterone following acute furosemide challenge were markedly blunted in the presence of indomethacin. In light of recent development indicating an intimate relationship between prostaglandins and renin release, these results provide further evidence for a pivotal role of renal prostaglandins in modulating the responsiveness of the renin-angiotensin-aldosterone axis in Mam.
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Tan et al. (1977) studied this question.
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