Why the study?
Does meloxicam or indomethacin reduce furosemide-stimulated plasma renin activity in healthy female volunteers?
Population
15 healthy female volunteers
Comparison
Meloxicam 7.5 mg/d for 6 days or indomethacin 25… vs No NSAID (control day)
Design
RCT, randomized cross-over design
Follow-up
6 days
Authors
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May warrant caution with NSAIDs plus loop diuretics; extends evidence that COX-2 mediates stimulated renin release in humans.
Does meloxicam or indomethacin reduce furosemide-stimulated plasma renin activity in healthy female volunteers?
Selective COX-2 inhibition with meloxicam inhibits furosemide-stimulated renin release, suggesting COX-2 mediates prostaglandin-dependent renin release in humans.
Stichtenoth et al. (1998) studied this question.
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