Population
Male Sprague-Dawley rats
Comparison
Selective COX-2 inhibitor NS 398 for 14 days or… vs Controls (no COX inhibitor)
Design
Preclinical
Follow-up
Up to 14 days
Authors
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No immediate clinical implications; hypothesis-generating for COX-2 in macula densa renin regulation.
COX-2 induction appears to be a component of the chronic stimulation of plasma renin activity by dietary sodium restriction via the macula densa pathway.
Harding et al. (2000) studied this question.
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