Why the study?
Does COX-2 inhibition with SC-58236 reduce renin expression and activity in adult rat kidneys?
Does COX-2 inhibition with SC-58236 reduce renin expression and activity in adult rat kidneys?
COX-2 activity determines the basal set point of the renin system in rat kidneys but is dispensable for the acute upregulation of renin expression.
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COX-2 inhibition may set basal renin tone in rats without blocking acute responses; extends mechanistic insight but leaves open human relevance.
Matzdorf et al. (2007) studied this question.
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