Why the study?
Does the selective COX-2 inhibitor SC58236 reduce renin production and blood pressure in a rat model of renovascular hypertension?
Population
Rats with renovascular hypertension induced by aortic coarctation between the right and left renal arteries
Comparison
Selective COX-2 inhibitor SC58236 administered… vs Vehicle administered for 1 week
Design
Preclinical
Follow-up
1 week
Authors
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Supports COX-2 role in experimental renovascular hypertension; hypothesis-generating and should not change practice.
Does the selective COX-2 inhibitor SC58236 reduce renin production and blood pressure in a rat model of renovascular hypertension?
Selective COX-2 inhibition decreases renin production and lowers blood pressure in a rat model of renovascular hypertension, suggesting an important role for COX-2 in regulating the renin-angiotensin system.
Wang et al. (1999) studied this question.
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