Population
Adult mice including neuronal nitric oxide synthase knockout and progenitor strains 129/SvEv and C57BL/6
Comparison
Low-sodium diet, selective nNOS inhibition, or… vs Normal sodium diet, wild-type progenitor…
Design
Preclinical
Authors
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Should not change clinical renin management; hypothesis-generating for differential nNOS versus COX-2 control of basal and stimulated renin.
Increased renal renin content in response to dietary sodium restriction requires COX-2 induction, while nNOS affects basal but not stimulated renin content.
Harding et al. (1997) studied this question.
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