In vitro renin release from rat kidney slices correlates with plasma renin activity in models of DOCA treatment and renal hypertension.
Validates in vitro kidney slice renin release as correlate of plasma activity in rat DOCA and hypertension models; leaves open human translation.
The release of renin by rat kidney slices in vitro using a simple short-term incubation procedure is reported. The in vivo-in vitro relationships were studied in DOCA-treated rats and in renal hypertensive rats. DOCA decreased the in vitro release of renin and also decreased plasma renin activity. In vitro release of renin at a supranormal level was detected during renal hypertension, while plasma renin activity was found to be enhanced. The reported changes in renin release were not necessarily correlated with changes of the renin content of the kidney.
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Wybren de Jong (1969) studied this question.
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