Why the study?
Does glucose affect renin release in rat kidney cortex slices?
Does glucose affect renin release in rat kidney cortex slices?
In vitro studies demonstrate that renin release from rat kidney cortex slices is glucose-dependent, supporting an active mechanism of renin secretion.
Glucose-dependent renin release in rat slices is hypothesis-generating; leaves open in vivo or human relevance and should not change practice.
A method for in vitro studies of renin release is described. Kidney cortex slices taken from control rats and rats stimulated to release renin were incubated with and without glucose. Renin release from the slices to a large extent was glucose-dependent. This result supports the hypothesis of an active mechanism of renin secretion.
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Bozović et al. (1969) studied this question.
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