This preclinical study demonstrates that in vitro renin release from rat kidney slices is an active process that can be modulated by dietary salt intake.
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High-salt suppression of renin in rat slices is hypothesis-generating; leaves open in vivo mechanisms and clinical translation.
This study was performed in order to evaluate the status of renin release from rat kidney slices. The results suggest that renin release in vitro is an active process occurring under both aerobic and anaerobic conditions. The rate of renin release is accelerated during the in vitro incubation, and any further stimulation with the addition of renin-stimulating drugs to the medium was not demonstrated. The rate of release could be depressed by placing the rat on a high-salt diet.
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Corsini et al. (1974) studied this question.
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