Population
Adult male Wistar rats (250-350g) on a regular diet (Na 260mg/100g); renal cortical slices
Comparison
Incubation with isoproterenol, furosemide… vs Incubation in buffer without any agents (control)
Design
Preclinical
Follow-up
60 minutes
Authors
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Hypothesis-generating for distinct active versus inactive renin pathways in rats; leaves open any human cardiovascular relevance.
The release mechanisms of active and inactive renin from rat renal cortical slices appear to be distinct, with submandibular gland extract stimulating inactive renin release and prostaglandins E1 and I2 inhibiting it.
Goi et al. (1990) studied this question.
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