Why the study?
Does the submandibular gland mediate the release of plasma inactive renin in response to various pharmacological agents in rats?
Population
Male Wistar rats (weight 250-350g) fed a normal diet
Comparison
Sialoadenectomy followed by administration of… vs Sham-operated control rats receiving the same…
Design
Preclinical
Follow-up
up to 240 minutes
Authors
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Hypothesis-generating for submandibular gland role in rodent renin release; leaves open human relevance or therapeutic implications.
Does the submandibular gland mediate the release of plasma inactive renin in response to various pharmacological agents in rats?
The submandibular gland is essential for furosemide-stimulated release of plasma inactive renin in rats.
Dodo et al. (1990) studied this question.
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