Population
Isolated glomeruli from rat kidney
Comparison
Decreasing sodium concentration from 140 to 110… vs Standard sodium concentration and absence of…
Design
Preclinical
Follow-up
3 h
Authors
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Isolated glomeruli model isolates direct JG effects; leaves open translation to human renin physiology and clinical relevance.
This study demonstrates a novel technique using isolated rat glomeruli to show that low sodium and catecholamines directly stimulate renin release independent of systemic hemodynamics or neural input.
Holdsworth et al. (1976) studied this question.
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