Population
In vitro preparations of rat glomeruli with short attached arterioles, single glomeruli with long attached…
Comparison
Isoprenaline (10 M) or a 30-mosmol/kg reduction… vs Baseline/control conditions
Design
Preclinical
Authors
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Extends in vitro mapping of juxtaglomerular cell heterogeneity; leaves open in vivo relevance and therapeutic implications.
This in vitro study demonstrates spatial functional heterogeneity of juxtaglomerular cells, with isoprenaline-sensitive cells located distally in the afferent arteriole and sodium chloride-sensitive cells located proximally to the glomerulus.
Baumbach et al. (1986) studied this question.
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