Why the study?
Does acute ACE inhibition with temocapril reduce the secretion of BNP and ANP during exercise in patients with essential hypertension?
Does acute ACE inhibition with temocapril reduce the secretion of BNP and ANP during exercise in patients with essential hypertension?
BNP and ANP are co-secreted from the heart during exercise, and this secretion is suppressed by acute ACE inhibition, suggesting a compensatory role against blood pressure elevation.
Authors
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Acute ACE inhibition may blunt exercise-induced natriuretic peptides in hypertension; hypothesis-generating and should not change practice.
Kohno et al. (1992) studied this question.
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