May 26, 2016Histopathology

BCOR–CCNB3‐positive soft tissue sarcoma with round‐cell and spindle‐cell histology: a series of four cases highlighting the pitfall of mimicking poorly differentiated synovial sarcoma

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Population

4 male patients with primary undifferentiated sarcomas of the deep musculature harbouring BCOR-CCNB3…

Design

Case_series

Follow-up

median 13.5 months

Authors

WLWan‐Shan LiChung Hwa University of Medical Technology ILI‐Chuang LiaoNational Sun Yat-sen University MWMei‐Chin WenChina Medical University

Discussion

Member takes

Implication

May warrant cyclin B3 testing in adult sarcomas mimicking synovial sarcoma; extends entity but leaves management open.

Structured PICO

Population

4 male patients (two teenagers aged 14 and 17 years, two adults aged 34 and 44 years) with primary undifferentiated sarcomas of the deep musculature harbouring BCOR-CCNB3 transcript

Outcome

Clinicopathological features, immunohistochemical profile, and clinical outcomes

BCOR-CCNB3-positive sarcomas can occur in soft tissues of adults, mimicking poorly differentiated synovial sarcomas, and cyclin B3 is a useful marker for selecting candidates for molecular testing.

Cite This Study

Li et al. (2016) studied this question.

synapsesocial.com/papers/6a83526d325a06cd088cf1a9 https://doi.org/10.1111/his.13001

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BCOR–CCNB3‐positive soft tissue sarcoma with round‐cell and spindle‐cell histology: a series of four cases highlighting the pitfall of mimicking poorly differentiated synovial sarcoma

Discussion

Member takes

Implication

Structured PICO

Cite This Study

BCOR–CCNB3‐positive soft tissue sarcoma with round‐cell and spindle‐cell histology: a series of four cases highlighting the pitfall of mimicking poorly differentiated synovial sarcoma

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider