Why the study?
Does rotigaptide increase the threshold for discordant alternans in Langendorff-perfused guinea pig hearts during ischemia?
Does rotigaptide increase the threshold for discordant alternans in Langendorff-perfused guinea pig hearts during ischemia?
Rotigaptide, a gap junction opener, suppresses arrhythmogenic discordant alternans and prevents connexin43 dephosphorylation during ischemia in guinea pig hearts, suggesting a novel antiarrhythmic strategy.
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Rotigaptide may attenuate ischemia-related arrhythmogenic substrate in guinea pigs; hypothesis-generating for gap junction modulation, with no clinical implications yet.
Kjølbye et al. (2007) studied this question.
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