Key result
In a rabbit model of chronic volume overload, rotigaptide significantly increased atrial conduction velocity but did not decrease susceptibility to the induction of atrial tachyarrhythmias.
Why the study?
Does rotigaptide improve atrial conduction velocity and reduce atrial tachyarrhythmia inducibility in a rabbit model of chronic volume overload?
Does rotigaptide improve atrial conduction velocity and reduce atrial tachyarrhythmia inducibility in a rabbit model of chronic volume overload?
In a rabbit model of chronic volume overload, rotigaptide successfully increased atrial conduction velocity but failed to prevent the inducibility of atrial tachyarrhythmias.
No takes yet. Share an insight, caveat, or question.
No reduction in inducibility despite faster conduction; leaves open whether gap junction modulation prevents AF.
Haugan et al. (2006) studied Chronic volume overload induced chronic atrial dilatation (n=24). Rotigaptide (ZP123) vs. Before treatment / Sham-operated controls was evaluated on Atrial conduction velocity and atrial tachyarrhythmias inducibility. In a rabbit model of chronic volume overload, rotigaptide significantly increased atrial conduction velocity but did not decrease susceptibility to the induction of atrial tachyarrhythmias.
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