Why the study?
Patients with persistent hypertension despite multiple medications are at high risk for adverse kidney events, and studies suggest a correlation between resistive index and renal function in kidney disease.
Does renal arterial resistive index (RRI) correlate with renal function in patients with resistant hypertension?
Does renal arterial resistive index (RRI) correlate with renal function in patients with resistant hypertension?
Renal arterial resistive index measured by Doppler ultrasound correlates with renal function markers in patients with resistant hypertension, suggesting its utility in evaluating renal prognosis.
RI index associated with renal impairment in resistant hypertension; leaves open prognostic value and clinical utility.
INTRODUCTION: There is a mutual relationship between hypertension and renal failure, so that hypertension can be considered as a common finding in patients with end-stage renal disorders. Patients with persistent hypertension despite multiple medications are at high risk for adverse cardiovascular and kidney events. Some studies suggest that there is a correlation between RI and renal function in kidney diseases. Therefore, we conducted a study to investigate the relationship between renal arterial resistive index (RRI) and renal outcomes in patients with resistant hypertension. METHODS: This 2-years cross-sectional study was performed on patients with resistant hypertension. All patients undergo GFR, serum Cr and urine Alb tests. Then Doppler ultrasound was performed by a radiologist to measure RRI and was evaluated for the relationship between RRI and renal function. RESULTS: Among 133 patients with resistant hypertension, 57.5% were male and the rest were female. Average age of participants and average RI were 48.26 ± 16.90 and 0.63 ± 0.80, respectively. There was no significant relationship between RI and gender (P > .05). Relationship between RI index with age, GFR, serum creatinine level, and albuminuria was significant in all cases (P < .05). Patients were divided into two groups with RI ≥ 0.7 and RI less than 0.7. Results showed a significant increase in serum creatinine and urinary albumin excretion in group with RI ≥ 0.7 (P < .05), while age, protein exertion level, and GFR in the two groups were not statistically significant (P > .05), despite the difference in the mean. Results of analysis of difference in the mean RI in 3 groups (macro-, micro-, normo- albuminuria) showed no significant difference between them (P > .05). CONCLUSION: These data demonstrate the clinical importance of renal Doppler that may be an effective way to evaluate the prognosis of renal involvement in resistant hypertension.
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Ghafori et al. (2020) studied this question.
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