Population
Glycerinated muscle fibers prepared from rabbit psoas
Comparison
Polyclonal antibody directed against the… vs Absence of the antibody
Design
Preclinical
Authors
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Supports myosin hinge role in force transmission independent of ATPase; hypothesis-generating for contractility mechanisms with no clinical implications yet.
Binding of anti-S-2 antibody to the myosin hinge region prevents myosin heads from contributing to force generation and stiffness without affecting their ability to hydrolyze ATP.
Sugi et al. (1992) studied this question.
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