Population
Rabbit skeletal myofibrils (rabbit psoas myofibrils)
Comparison
Affinity-column-purified polyclonal antibodies… vs Control (untreated) myofibrils in rigor buffer
Design
Preclinical
Authors
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Distinguishes myosin subfragment-2 contribution to force from shortening in animal myofibrils; leaves open relevance to human cardiac function.
The subfragment-2 region of myosin contributes to force production in actively contracting muscle, while the myosin head alone may be sufficient for unloaded shortening.
Harrington et al. (1990) studied this question.
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