Why the study?
Does C-type natriuretic peptide inhibit thrombin- and angiotensin II-stimulated endothelin-1 secretion in cultured porcine endothelial cells compared to ANP and BNP?
Population
Cultured porcine endothelial cells
Comparison
Porcine C-type natriuretic peptide (CNP-22) vs Porcine atrial natriuretic peptide (ANP) and…
Design
Preclinical
Authors
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CNP-22 may offer superior endothelial modulation in porcine cells; hypothesis-generating and leaves open any human therapeutic role.
Does C-type natriuretic peptide inhibit thrombin- and angiotensin II-stimulated endothelin-1 secretion in cultured porcine endothelial cells compared to ANP and BNP?
CNP potently inhibits endothelin-1 secretion in endothelial cells via a cyclic GMP-dependent mechanism, showing greater efficacy than ANP or BNP.
Kohno et al. (1992) studied this question.
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