Population
Porcine aorta and cultured porcine endothelial cells
Comparison
Porcine atrial natriuretic peptide (ANP-) and… vs Angiotensin II stimulation without ANP/BNP
Design
Preclinical
Authors
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Does not support clinical use; hypothesis-generating for cGMP-mediated ET-1 inhibition in porcine endothelium, requiring human validation.
ANP and BNP inhibit Ang II-stimulated endothelin-1 secretion in porcine endothelial cells, likely via a cGMP-dependent mechanism.
Kohno et al. (1992) studied this question.
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