Why the study?
Does aspirin exposure increase the risk of serious upper gastrointestinal complications?
Population
17 original epidemiologic studies published between 1990 and 2001
Comparison
Aspirin exposure vs Non-use of aspirin
Design
Meta-analysis
Authors
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Aspirin elevates UGIC risk; reinforces observational association and supports gastroprotection in at-risk patients.
Does aspirin exposure increase the risk of serious upper gastrointestinal complications?
Aspirin use, even at low doses or in buffered/enteric-coated formulations, is associated with a significantly increased risk of serious upper gastrointestinal complications.
Luis A. Garcı ́a Rodrı ́guez (2001) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: