September 1, 1990British Journal of PharmacologyOpen Access

Pharmacological evidence for the existence of a local renin‐angiotensin system in porcine interlobar renal arteries

View Full Paper

Ask AI

Bookmark

Population

Ring preparations from porcine interlobar renal arteries

Design

Preclinical

Authors

EMElse Müller‐SchweinitzerUniversity Hospital of Basel IOItziar Olea‐BazaJain PharmaBiotech (Switzerland)

Discussion

Member takes

Implication

Hypothesis-generating for local RAS in renal vessels; should not change practice and requires human validation.

Structured PICO

Population

Ring preparations from porcine interlobar renal arteries

Intervention

Cumulative additions of angiotensins (angiotensinogen, angiotensin I, angiotensin II), bradykinin, and acetylcholine, with various pharmacological inhibitors (indomethacin, NDGA, dazoxiben, tranylcypromine, saralasin, enalaprilic acid, kallikrein)

Outcome

Changes in isometric tension (contractile or relaxant responses)surrogate

Pharmacological evidence suggests that porcine interlobar renal arteries possess a local renin-angiotensin system with activatable angiotensin II-forming enzymes within the vessel wall.

Cite This Study

Müller‐Schweinitzer et al. (1990) studied this question.

synapsesocial.com/papers/6a835e3ef41d4f5c6da0f77c https://doi.org/10.1111/j.1476-5381.1990.tb12094.x

View Full Paper

Ask AI

Bookmark

Pharmacological evidence for the existence of a local renin‐angiotensin system in porcine interlobar renal arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pharmacological evidence for the existence of a local renin‐angiotensin system in porcine interlobar renal arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider