September 1, 1978Stroke

Responses of isolated dog cerebral and peripheral arteries to prostaglandins after application of aspirin and polyphloretin phosphate.

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Population

Helically cut strips of dog cerebral, coronary, mesenteric and femoral arteries, and human cerebral arteries

Comparison

Application of aspirin (5 X 10 and 2 X 10 M) and… vs Responses to prostaglandins without aspirin or…

Design

Preclinical

Authors

NTNoboru TodaToyama College MMMizuo MiyazakiOsaka Medical and Pharmaceutical University

Discussion

Member takes

Implication

May warrant caution with aspirin in prostaglandin-sensitive vessels; leaves open translation from isolated artery findings to clinical practice.

Structured PICO

Population

Helically cut strips of dog cerebral, coronary, mesenteric and femoral arteries, and human cerebral arteries

Intervention

Application of aspirin (5 X 10(-5) and 2 X 10(-4) M) and polyphloretin phosphate (3 X 10(-5) and 10(-4) g/ml) prior to prostaglandin (PGF2alpha, E2, E1) exposure

Comparator

Responses to prostaglandins without aspirin or polyphloretin phosphate, or relative to contractions induced by K+ and relaxations induced by papaverine

Outcome

Contractile and relaxing responses of the isolated arteriessurrogate

In isolated dog and human arteries, aspirin potentiates and polyphloretin phosphate attenuates the vasoconstricting effects of prostaglandins without affecting their vasodilating effects.

Cite This Study

Toda et al. (1978) studied this question.

synapsesocial.com/papers/6a835e3ef41d4f5c6da0f787 https://doi.org/10.1161/01.str.9.5.490

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Implication

May warrant caution with aspirin in prostaglandin-sensitive vessels; leaves open translation from isolated artery findings to clinical practice.