January 1, 1975The Japanese Journal of PharmacologyOpen Access

Different Inotropic Responses to Adenosine on the Atrial and Ventricular Muscle of the Dog Heart

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Population

Isolated canine coronary, femoral, mesenteric, and renal arterial strips

Design

Preclinical

Authors

SCShigetoshi ChibaMount Sinai Hospital NHNorio HimoriRoche (Japan)

Discussion

Member takes

Implication

PGE1 relaxation and PGE2 contraction in canine arteries should not guide clinical use; leaves open differential prostaglandin effects on human coronary tone.

Structured PICO

Population

Isolated canine coronary, femoral, mesenteric, and renal arterial strips

Intervention

Prostaglandin E1 (PGE1) and Prostaglandin E2 (PGE2)

Outcome

Vascular smooth muscle relaxation or contractionsurrogate

PGE1 and PGE2 exert opposite vasomotor effects on isolated canine arteries, with PGE1 inducing relaxation and PGE2 inducing contraction.

Cite This Study

Chiba et al. (1975) studied this question.

synapsesocial.com/papers/6a906d19ed78fcc1e60d386b https://doi.org/10.1254/jjp.25.489

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Implication

PGE1 relaxation and PGE2 contraction in canine arteries should not guide clinical use; leaves open differential prostaglandin effects on human coronary tone.

Different Inotropic Responses to Adenosine on the Atrial and Ventricular Muscle of the Dog Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Different Inotropic Responses to Adenosine on the Atrial and Ventricular Muscle of the Dog Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider