Thirty-six patients with Cushing’s disease underwent transsphenoidal surgery at the Cleveland Clinic between January 1976 and August 1986. Adenomas were identified, removed, and verified pathologically in 28 patients (78%); in all cases, hypercortisolism was corrected. Overall, 31 of the 36 patients (8 6 %) were cured initially (biochemically and clinically). No operative mortality or permanent neurological sequelae were sustained. Follow-up ranged from four to 120 months. There have been three recurrences after an initial apparent cure.
No takes yet. Share an insight, caveat, or question.
Bay et al. (1988) studied this question.