HELMET PROTOCOL: Granulation tissue as Dura autologous-graft. Model in Wistar Rats

Nowadays dura surgery has variable options in duroplasty, autologous grafts, homologous grafts, heterologous grafts and synthetic implants.They still have disadvantages, and some of them are not used.Dura is the hardest of all the meninges, composed by a dense conjunctive tissue matrix.It is covered by a at epithelium called mesothelium.It has two sections, endosteum \(external layer) and meningeal \(internal layer).Its function is to provide mechanical support and to isolate the central nervous system \(CNS).Dura integrity is critical to avoid: trauma, infection, leakage of CSF and adherence of brain tissue to other structures 1 .The aim of this protocol, experimental animal model in Wistar rats, is to create an immunologically -compatible graft with the host and use it as a replacement dura.Currently the author's institution does not have the resources to carry out this protocol.Research resources in Mexico are destined for higher incidence diseases \(such as hypertension and diabetes) rather than diseases of the dura.This protocol is proposed by the author as an approach that he would like to see done by a research team with appropriate resources and interest in this eld.