Population
Human tumor cells in tissue culture (including excision repair-competent and excision-deficient cells)
Comparison
Doxorubicin, doxorubicin C-14 derivatives, and… vs X-irradiation alone, or different exposure…
Design
Preclinical
Authors
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Should not yet change chemoradiotherapy scheduling; leaves open whether cell survival-dependent synergy translates clinically.
Doxorubicin and X-irradiation demonstrate synergistic cytotoxicity at low cell survival levels, suggesting shared mechanisms of DNA damage that may inform clinical chemoradiotherapy scheduling.
Byfield et al. (1977) studied this question.
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