Population
25 cases of cross-sectional image-negative hyperaldosteronism
Design
Cohort
Authors
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Classification by micronodules vs hyperplasia may refine image-negative PA etiology; leaves open whether mutation status alters management.
Morphologic evaluation and CYP11B2 immunohistochemistry can classify image-negative hyperaldosteronism into multiple micronodules or diffuse hyperplasia, revealing that somatic mutations commonly drive aldosterone overproduction in micronodules.
Yamazaki et al. (2016) studied this question.
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