January 1, 2003Journal of Pediatric Endocrinology and Metabolism

Coexistence of Impaired Indices of Autonomic Neuropathy and Diabetic Nephropathy in a Cohort of Children with Type 1 Diabetes Mellitus

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Structured PICO

Population

129 children with type 1 diabetes mellitus (mean age 12.4 +/- 3.4 years, mean DM duration 4.5 +/- 3.2 years, mean HbA1c 11.1 +/- 2.2%) and 144 age- and sex-matched control children from a county population.

Comparator

144 age- and sex-matched control children

Outcome

Indices of sympathetic dysfunction (pupillary adaptation in darkness), incipient nephropathy (urinary albumin/creatinine ratio), and cardiovascular autonomic dysfunction (heart rate variation)surrogate

In children with type 1 diabetes, indices of diabetic nephropathy and cardiovascular autonomic neuropathy frequently coexist and are associated with longer disease duration and poorer glycemic control.

Authors

KKKyriaki KaravanakiNational and Kapodistrian University of Athens JBJ D BaumLaboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier

Discussion

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Implication

Pupillary testing may flag early autonomic neuropathy in children with DM; hypothesis-generating and requires prospective validation before screening adoption.

Cite This Study

Karavanaki et al. (2003) studied this question.

synapsesocial.com/papers/6a836a11e01485c92eeefdc1 https://doi.org/10.1515/jpem.2003.16.1.79

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Implication

Pupillary testing may flag early autonomic neuropathy in children with DM; hypothesis-generating and requires prospective validation before screening adoption.

Coexistence of Impaired Indices of Autonomic Neuropathy and Diabetic Nephropathy in a Cohort of Children with Type 1 Diabetes Mellitus

Structured PICO

Discussion

Implication

Cite This Study

Coexistence of Impaired Indices of Autonomic Neuropathy and Diabetic Nephropathy in a Cohort of Children with Type 1 Diabetes Mellitus

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider