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March 1, 1994Arteriosclerosis and Thrombosis A Journal of Vascular BiologyOpen Access

Effects of candidate autocrine and paracrine mediators on growth responses in isolated rat arteries.

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Population

Isolated segments of carotid and renal arteries from adult rats, with and without endothelium

Comparison

Candidate autocrine and paracrine mediators in… vs Control conditions

Design

Preclinical

Follow-up

3 days to long-term culture

Authors

PSPaul SchiffersMaastricht UniversityGFGregorio E. FazziMaastricht UniversityDSDorette van Ingen SchenauPrincess Máxima Center

Discussion

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Implication

These rat artery findings warrant no clinical vascular interventions; leaves open distinct autocrine/paracrine control of medial versus extramedial proliferation for further study.

Structured PICO

P
Population
Isolated segments of carotid and renal arteries from adult rats, with and without endothelium
I
Intervention
Candidate autocrine and paracrine mediators (basic fibroblast growth factor, endothelin-1, interleukin-1, transforming growth factor-beta, insulin-like growth factor-1, platelet-derived growth factor AA, platelet-derived growth factor BB, and angiotensin II) in tissue culture
C
Comparator
Control conditions (moderate stimulation, presence/absence of endothelium, presence/absence of L-arginine or nitric oxide synthase inhibitor)
O
Outcome
Medial DNA synthesis and extramedial cell proliferationsurrogate

Different autocrine and paracrine factors distinctively regulate medial DNA synthesis and extramedial cell proliferation in isolated rat arteries, with endothelial modulation appearing independent of prostaglandins, nitric oxide, or interleukin-1.

Cite This Study

Schiffers et al. (1994) studied this question.

synapsesocial.com/papers/6a836d6e7ea419b390a6ceaehttps://doi.org/10.1161/01.atv.14.3.420
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Monoclonal Antibody to 5-Bromo- and 5-Iododeoxyuridine: A New Reagent for Detection of DNA Replication1982 · 2,655 citations
  2. 2Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet‐derived growth factor‐like protein which is secreted1987 · 228 citations
  3. 3Acute and long-term effects of tissue culture on contractile reactivity in renal arteries of the rat.1989 · 54 citations
  4. 4Transforming growth factor-beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells.1988 · 301 citations
  5. 5Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner1988 · 205 citations