Population
Cultured human newborn aortic smooth muscle cells
Comparison
Angiotensin II treatment on different… vs Different extracellular matrix surfaces or…
Design
Preclinical
Follow-up
up to 72 hours
Authors
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Should not yet change hypertension practice; hypothesis-generating for ECM-dependent Ang II effects on VSMC proliferation.
Angiotensin II-induced proliferation in human vascular smooth muscle cells is dependent on extracellular matrix proteins and regulated by differential gene expression of Egr-1 and PDGF-1 via the AT1 receptor.
Ling et al. (1999) studied this question.
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