March 25, 2009Journal of Cerebral Blood Flow & MetabolismOpen Access

Rapid Reversal of Anticoagulation Reduces Hemorrhage Volume in a Mouse Model of Warfarin-Associated Intracerebral Hemorrhage

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Why the study?

Does human prothrombin complex concentrate reduce hemorrhagic blood volume in a mouse model of warfarin-associated intracerebral hemorrhage?

Population

Male CD-1 mice treated with warfarin resulting in mean INR 3.5+/-0.9, subjected to stereotactic injection of…

Comparison

Human prothrombin complex concentrate 100 U/kg… vs Saline i.v.

Design

Preclinical, randomly treated

Follow-up

24 hours

Authors

CFChristian FoerchGoethe University Frankfurt KAKen AraiThe Graduate University for Advanced Studies, SOKENDAI ECElizabeth M. Van CottBoston University

Discussion

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Implication

Reduces hemorrhagic volume in warfarin-ICH mice; hypothesis-generating and should not change clinical practice.

Structured PICO

Does human prothrombin complex concentrate reduce hemorrhagic blood volume in a mouse model of warfarin-associated intracerebral hemorrhage?

Population

Male CD-1 mice treated with warfarin (2 mg/kg over 24 h) resulting in mean INR 3.5+/-0.9, subjected to stereotactic injection of collagenase to induce hemorrhage in the right striatum (n=24).

Intervention

Human prothrombin complex concentrate (PCC) 100 U/kg i.v. administered 45 minutes after hemorrhage induction.

Comparator

Saline i.v.

Outcome

Hemorrhagic blood volume quantified using a photometric hemoglobin assay 24 hours after hemorrhage induction.surrogate

Human prothrombin complex concentrate effectively reduces hemorrhagic blood volume in a mouse model of warfarin-associated intracerebral hemorrhage.

Cite This Study

Foerch et al. (2009) studied this question.

synapsesocial.com/papers/6a8372c3df262e78b0720f3e https://doi.org/10.1038/jcbfm.2009.27

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Rapid Reversal of Anticoagulation Reduces Hemorrhage Volume in a Mouse Model of Warfarin-Associated Intracerebral Hemorrhage

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rapid Reversal of Anticoagulation Reduces Hemorrhage Volume in a Mouse Model of Warfarin-Associated Intracerebral Hemorrhage

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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